Landis Zimmerman, vice president and chief investment officer of the Howard Hughes Medical Institute, will retire later this year, confirmed Jim Keeley, spokesman for the $21 billion endowment.
An official departure date for Mr. Zimmerman's retirement has not been specified.
Mr. Zimmerman said in a news release that it was "difficult to leave HHMI," but that he was "confident that (the) endowment is in very good hands."
Mr. Zimmerman has been CIO of the institute since 2004.
HHMI has retained executive search firm David Barrett Partners to seek a replacement. Mr. Keeley added that the institute does not anticipate a gap between Mr. Zimmerman leaving and hiring a new CIO.