Stephen Blyth, president and CEO of Harvard Management Co., will take a temporary medical leave of absence, effective Monday, said spokeswoman Emily Guadagnoli.
Robert Ettl, HMC's chief operating officer, has been appointed interim CEO until Mr. Blyth's return.
In the interim period, Rene Canezin, managing director and head of fixed income, credit and commodities, and Rich Hall, managing director and head of private equity, will serve as co-chairs of Harvard Management Co.'s investment committee.
Harvard Management Co. manages Cambridge, Mass.-based Harvard University's $37.6 billion endowment.
Mr. Blyth was named president and CEO of HMC on Jan. 1, 2015, replacing Jane Mendillo, who retired.